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Avodart (Dutasteride)

Avodart – drug in capsules, which acts directly on the prostate tissue, reducing its dimensions, and is intended for the treatment and prevention of benign prostate tumors. It also reduces the risk of acute urinary retention, eliminating the need for surgery. Avodart capsules made of gelatin, yellow, produced in blister packs of ten capsules, three […]

Avodart (Dutasteride)Avodart – drug in capsules, which acts directly on the prostate tissue, reducing its dimensions, and is intended for the treatment and prevention of benign prostate tumors. It also reduces the risk of acute urinary retention, eliminating the need for surgery.

Avodart capsules made of gelatin, yellow, produced in blister packs of ten capsules, three or nine blisters in the package. It may appoint in conjunction with other drugs that affect hormone metabolism. Its price usually ranges from 1,500 to 2,500 rubles for thirty capsules.

Avodart mechanism of action, indications for use

The active ingredient Avodart – dutasteride. It affects the hormonal metabolism of the prostate gland, due to which the hormone-dependent tissue is reduced in size without surgery. Write mainly in the feces, it is processed by the liver.

Tests were conducted on groups of men between 18 and 87 years of age did not play value in the treatment of drug, elderly people carry it no worse than the young. According to the instructions shown Avodart men with benign prostate cancer, prostate hyperplasia, as well as acute urinary retention.

Contraindications

Contraindications to the use of only serves hypersensitivity to the drug. When diagnosed with liver failure Avodartsleduet used with caution. Do not take it as women and children, since there is no data on the use of the drug in them.

Dosage Avodart

By taking Avodart instructions regardless of the meal, one capsule once a day. One capsule contains 0.5 mg of active substance. Do not open or chew the capsule, since the drug causes irritation of the mucous membranes of the mouth and throat. Overdose occurs rarely, if occurs, the treatment can be carried out by the symptoms, there is no specific antidote.

Side Effects Avodart

 

Very rarely (less than one case per ten thousand) possible violation of potency, decreased sexual desire, allergic reactions, increase in mammary glands. Occasionally there is baldness, hair fall mainly on the body. Possible pain in the testicles, and depression. Interaction with other drugs clinically unimportant.

Avodart reduces sperm count about twice, reducing their mobility and the number of sperm with long-term (longer than 52 weeks) administration. However, after the discontinuation of these indicators are restored.

Features of the drug

Dutasteride, which is part of Avodart, is able to penetrate through the skin, so you should avoid contact with damaged capsules to people who did not take, especially children. In case of contact, immediately wash the contaminated skin with soap and water.

When the drug is not difficult to diagnose prostate cancer, but before use, make sure benign tumors and in the process constantly monitor room her condition as during clinical trials it has been observed a slight increase in the number of cases of degeneration of benign prostatic hyperplasia in cancer in people taking the drug.

Comments about Avodart

Subjective improvement of health in the patients receiving Avodart comes quickly, but it is necessary to take at least six months, so that the effect can be assessed objectively. Negative reviews are caused mainly by the fact that the patient does not maintain the required reception time. Sometimes there is a reduced sensitivity of the prostate gland hormone, then may appear insufficient feedback on the effectiveness of the drug, but this happens very rarely.

On the side effects complaints are also very rare, usually well tolerated. Reviews from physicians urology and andrology usually also positive. If you experience side effects in the patient and his complaints and sharply negative reviews about Avodart drug overturned.

Pharmacological Effects
Dutasteride inhibitory effect on 5α-reductase isozymes of both types. That it stops the conversion of testosterone to the androgen DHT, which is associated with the development of hyperplastic changes in the tissues of the prostate (RV). In drug treatment, a decrease in plasma concentrations of 85-90% DHT. The therapy following changes are observed drug Avodart:
– a decrease in size of the prostate;
– Improvement of urination;
– Reduce the likelihood of acute urinary retention;
– Reducing the need for surgical intervention.

 Indications

The drug Avodart is indicated for benign hyperplasia of the prostate character.

 

Dosage
Standard dosage capsules Avodart: 1 capsule / day. The capsule is used as a whole, without regard to meals. The course of treatment over six months. Dose adjustment for patients with renal insufficiency is not carried out.

Side effects
Receiving Avodart medication may be accompanied by:
– hives;
– Erectile dysfunction;
– Rash;
– Gynecomastia;
– Itching;
– Decreased libido;
– Localized swelling.

 

Contraindications
The drug Avodart is not indicated in case of:
– hypersensitivity to dutasteride;
– Hypersensitivity to the auxiliary components;
– Hypersensitivity to inhibitors of 5α-reductase.

With care prescribe Avodart with hepatic insufficiency.

 

Pregnancy
The drug is absolutely contraindicated and not appropriate to the destination pregnant.

 

Drug interactions

The drug, a group of drugs Possible interactions result
verapamil Reduced clearance of dutasteride
Diltiazem Reduced clearance of dutasteride

 

Overdose
No cases of overdose with severe symptoms have been recorded. Antidote No specific nature. If you notice any unusual symptoms should seek qualified therapeutic help.

 

Product form
The drug is available in capsule form. Filling Machine are as follows:
– 30 capsules / pack;
– 90 capsules / pack.

 

Storage conditions
Storage temperature Avodart capsules – up to 30 degrees Celsius. The suitability of the drug for use – 4 years.

 

Ingredients
1 capsule contains dutasteride Avodart 500 mg. Auxiliary components: mono-, di-glycerides of capric / caprylic acids, gelatin, butylhydroxytoluene, yellow iron oxide, glycerol, titanium dioxide.

 

Therapeutic

Drugs used for diseases of the prostate

The nosological classification (ICD-10)

Prostatic hyperplasia (N40)

 

The active ingredient is:  dutasteride

 

ATC:  G04CB02

 

Manufacturer:  by GlaxoSmithKline

 

Additionally,
with damage to the capsules can not be contacted his hands, as the drug penetrates through the skin.
Before and during the treatment it is carried out a study of the prostate gland, PSA determination.
At the rate of reaction does not affect Avodart medication.

 

Attention!
Description “of the drug Avodart ” on this page is a simplified and enlarged version of the official instructions for use. Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer.
Preparation of information being provided is for informational purposes and should not be used as a guide to self-healing. Only a doctor can decide on the appointment of the drug, and to determine the doses and methods of application.